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Nucleic acid-based diagnostics for infectious diseases in public health affairs

Albert Cheung-Hoi Yu, Greg Vatcher, Xin Yue, Yan Dong, Mao Hua Li, Patrick H. K. Tam, Parker Y.L. Tsang, April K.Y. Wong, Michael H.K. Hui, Bin Yang, Hao Tang, Lok-Ting Lau

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 173-186 doi: 10.1007/s11684-012-0195-5

Abstract: Many kinds of diagnostics have been developed, such as pathogen culture, biochemical tests and serologicalNucleic acid-based diagnostics, detecting pathogens through the identification of their genomic sequencesHere we review some of the most popular nucleic acid-based diagnostics and focus on their adaptabilityWe also compare and contrast the characteristics of different types of nucleic acid-based diagnostics

Keywords： nucleic acid-based diagnostics     infectious disease     PCR     NASBA     LAMP     microarray     LOAC     public health affairs    

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Design of nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleicacid drugs: learning from virus

Vaibhav Mundra, Ram I. Mahato

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 387-404 doi: 10.1007/s11705-014-1457-3

Abstract: many challenges in developing efficient and target specific delivery systems of small molecule and nucleicacid drugs.Finally, we highlight the important design elements of recent virus-based nanocarriers for efficient

Keywords： nanocarrier     cellular uptake     endosomal release     nucleic acid drug    

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A boronic acid-based fluorescent hydrogel for monosaccharide detection

Suying Xu, Adam C. Sedgwick, Souad A. Elfeky, Wenbo Chen, Ashley S. Jones, George T. Williams, A. Toby A. Jenkins, Steven D. Bull, John S. Fossey, Tony D. James

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 1,   Pages 112-116 doi: 10.1007/s11705-019-1812-5

Abstract: A boronic acid-based anthracene fluorescent probe was functionalised with an acrylamide unit to incorporateThe hydrogel incorporating the boronic acid monomer demonstrated the ability to detect monosaccharides
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Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom

Wen Zhang,Jack W. Szostak,Zhen Huang

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 196-202 doi: 10.1007/s11705-016-1565-3

Abstract: X-ray crystallography is a powerful strategy for 3-D structure determination of macromolecules, such as nucleicacids and protein-nucleic acid complexes.Recently we have successfully developed synthesis and strategy of selenium-derivatized nucleic acids(SeNA) for nucleic acid crystallography.

Keywords： selenium     DNA     RNA     nucleic acid     crystallization    

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Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 3,   Pages 275-286 doi: 10.1007/s11705-011-1203-z

Abstract: Polymer-based conjugates are an interesting option and challenge for the design of nano-sized drug-deliveryIn the case of nucleic acid therapy, non-viral carriers face several biological barriers during the deliveryengineering and conjugation of multifunctional polymeric structures for the utilization as “tailor-made” nucleicacid carriers.

Keywords： conjugate     DNA     gene transfer     polymer     RNA     targeting    

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Fluorescent properties and

Hong GAO,Jie SONG,Shibin SHANG,Zhanqian SONG

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 1,   Pages 106-115 doi: 10.15302/J-FASE-2017133

Abstract: A series of dehydroabietic acid-based diarylamines have been synthesized in order to investigate their

Keywords： dehydroabietic acid-based diarylamine     DFT study     fluorescent probe     in vitro imaging    

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Validation of polarizable force field parameters for nucleic acids by inter-molecular interactions

Liaoran Cao,Hong Ren,Jing Miao,Wei Guo,Yan Li,Guohui Li

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 203-212 doi: 10.1007/s11705-016-1572-4

Abstract: Modeling structural and thermodynamic properties of nucleic acids has long been a challenge in the developmenthave been proved to be reliable to model small molecules, polypeptides and proteins, but their use on nucleicIn this article, the interactions between nucleic acids and a small molecule or ion were modeled by AMOEBAbio09

Keywords： nucleic acid     polarizable force field     AMOEBA    

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Development Trends and Suggestions of Nucleic Acid Vaccines

Li Aihua, Yang Xuemei, Sun Yinan, Yuan Yakun, Yang Juntao

Strategic Study of CAE 2021, Volume 23, Issue 4,   Pages 153-161 doi: 10.15302/J-SSCAE-2021.04.018

Abstract: This article first summarizes the R&D status of nucleic acid vaccines from the aspects of relatedacid vaccines.acid vaccines, and studies the possible technical and safety problems.Furthermore, we suggest that the key technologies of nucleic acid vaccines should be developed by improvingMoreover, the safety and efficacy of nucleic acid vaccines should be strictly monitored; stakeholders

Keywords： nucleic acid vaccine     deoxyribonucleic acid (DNA) vaccine     ribonucleic acid (RNA) vaccine     messenger    

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Flow cytometric assessment of the effects of chlorine, chloramine, and UV on bacteria by using nucleicacid stains and 5-cyano-2,3-ditolyltetrazolium chloride

Xuebiao Nie, Wenjun Liu, Mo Chen, Minmin Liu, Lu Ao

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 6, doi: 10.1007/s11783-016-0884-4

Abstract: Flow cytometry based on nucleic acid stains and CTC was established and optimized.This study detected the metabolic activity of and by using an FCM method based on 5-cyano-2,3-ditolyltetrazoliumChlorine demonstrated stronger and faster destructive effects on cytomembrane than chloramine, and nucleic

Keywords： Flow cytometry     Escherichia coli     Staphylococcusaureus     UV     CTC     SYTO 9    

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Basic research on machinery fault diagnostics: Past, present, and future trends

Xuefeng CHEN, Shibin WANG, Baijie QIAO, Qiang CHEN

Frontiers of Mechanical Engineering 2018, Volume 13, Issue 2,   Pages 264-291 doi: 10.1007/s11465-018-0472-3

Abstract: Research on machinery Fault diagnostics has grown rapidly in recent years.aspects: Fault mechanism, sensor technique and signal acquisition, signal processing, and intelligent diagnosticsThe review discusses the special contributions of Chinese scholars to machinery fault diagnostics.

Keywords： fault diagnosis     fault mechanism     feature extraction     signal processing     intelligent diagnostics    

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Strategic Research on the Molecular Diagnostics Industry in China

Xie Lan,Liu Ran,Feng Juan,Xing Wanli and Cheng Jing

Strategic Study of CAE 2017, Volume 19, Issue 2,   Pages 29-36 doi: 10.15302/J-SSCAE-2017.02.005

Abstract:

Molecular diagnostics is an important part of personalized medicine andhas become the main driving force of the in vitro diagnostics industry.In recent years, China's molecular diagnostics industry has been growing rapidly, despite its smallBased on literature research, expert interviews, and field investigation, we performed an intensive marketanalysis of the current situation of the domestic molecular diagnostics industry.

Keywords： molecular diagnostics     in vitro diagnostics     market analysis     policies and regulations     biochip    

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Modelling and diagnostics of multiple cathodes plasma torch system for plasma spraying

Kirsten BOBZIN, Nazlim BAGCIVAN, Lidong ZHAO, Ivica PETKOVIC, Jochen SCHEIN, Karsten HARTZ-BEHREND, Stefan KIRNER, José-Luis MARQUéS, Günter FORSTER

Frontiers of Mechanical Engineering 2011, Volume 6, Issue 3,   Pages 324-331 doi: 10.1007/s11465-011-0125-2

Abstract:

Usage of a multiple-arcs system has significantly improved process stability and coating properties in air plasma spraying. However, there are still demands on understanding and controlling the physical process to determine process conditions for reproducible coating quality and homogeneity of coating microstructure. The main goal of this work is the application of numerical simulation for the prediction of the temperature profiles at the torch outlet for real process conditions. Behaviour of the gas flow and electric arcs were described in a three-dimensional numerical model. The calculated results showed the characteristic triangular temperature distribution at the torch nozzle outlet caused by three electric arcs. These results were compared with experimentally determined temperature distributions, which were obtained with specially developed computed tomography equipment for reconstructing the emissivity and temperature distribution of the plasma jet close to the torch exit. The calculated results related to temperature values and contours were verified for the most process parameters with experimental ones.

Keywords： plasma spraying     electric arc     three-cathode plasma torch     numerical simulation     computed tomography    

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Novel X-ray and Optical Diagnostics for Studying Energetic Materials: A Review Review

Yiyang Zhang, Sen Chen, Yang Cai, Lei Lu, Duan Fan, Jinchun Shi, Junyu Huang, Sheng-Nian Luo

Engineering 2020, Volume 6, Issue 9,   Pages 992-1005 doi: 10.1016/j.eng.2020.06.019

Abstract: acquiring new data, and understanding underlying mechanisms all require temporally and spatially resolved diagnosticsHere, we present a brief review of novel diagnostics that are either emerging or have existed but rarelyscattering, terahertz and optical absorption/emission spectroscopy, and one-dimensional (1D) and 2D laser-based

Keywords： Energetic materials     X-ray     Terahertz and optical diagnostics     Multiscale measurements    

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The research progress of laser combustion diagnostics techniques and applications

Hu Zhiyun,Liu Jingru,Zhang Zhenrong,Ye Jingfeng,Guan Xiaowei,Zhang Lirong,Wang Sheng,Huang Meisheng,Zhao Xinyan,Ye Xisheng

Strategic Study of CAE 2009, Volume 11, Issue 11,   Pages 45-50

Abstract: Techniques based on these measurement concepts can monitor a variety of parameters including temperatureThe experimental results were given by these laser-based methods in premixed flame, solid propellant

Keywords： laser     combustion diagnostics     propellant     supersonic flowfield    

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Title Author Date Type Operation

Nucleic acid-based diagnostics for infectious diseases in public health affairs

Albert Cheung-Hoi Yu, Greg Vatcher, Xin Yue, Yan Dong, Mao Hua Li, Patrick H. K. Tam, Parker Y.L. Tsang, April K.Y. Wong, Michael H.K. Hui, Bin Yang, Hao Tang, Lok-Ting Lau

Journal Article

Design of nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleicacid drugs: learning from virus

Vaibhav Mundra, Ram I. Mahato

Journal Article

A boronic acid-based fluorescent hydrogel for monosaccharide detection

Suying Xu, Adam C. Sedgwick, Souad A. Elfeky, Wenbo Chen, Ashley S. Jones, George T. Williams, A. Toby A. Jenkins, Steven D. Bull, John S. Fossey, Tony D. James

Journal Article

Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom

Wen Zhang,Jack W. Szostak,Zhen Huang

Journal Article

Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Journal Article

Fluorescent properties and

Hong GAO,Jie SONG,Shibin SHANG,Zhanqian SONG

Journal Article

Validation of polarizable force field parameters for nucleic acids by inter-molecular interactions

Liaoran Cao,Hong Ren,Jing Miao,Wei Guo,Yan Li,Guohui Li

Journal Article

Development Trends and Suggestions of Nucleic Acid Vaccines

Li Aihua, Yang Xuemei, Sun Yinan, Yuan Yakun, Yang Juntao

Journal Article

Flow cytometric assessment of the effects of chlorine, chloramine, and UV on bacteria by using nucleicacid stains and 5-cyano-2,3-ditolyltetrazolium chloride

Xuebiao Nie, Wenjun Liu, Mo Chen, Minmin Liu, Lu Ao

Journal Article

Basic research on machinery fault diagnostics: Past, present, and future trends

Xuefeng CHEN, Shibin WANG, Baijie QIAO, Qiang CHEN

Journal Article

Strategic Research on the Molecular Diagnostics Industry in China

Xie Lan,Liu Ran,Feng Juan,Xing Wanli and Cheng Jing

Journal Article

Li Aihua: Development Trends and Suggestions of Nucleic Acid Vaccines (2021-9-3)

15 Oct 2021

Conference Videos

Modelling and diagnostics of multiple cathodes plasma torch system for plasma spraying

Kirsten BOBZIN, Nazlim BAGCIVAN, Lidong ZHAO, Ivica PETKOVIC, Jochen SCHEIN, Karsten HARTZ-BEHREND, Stefan KIRNER, José-Luis MARQUéS, Günter FORSTER

Journal Article

Novel X-ray and Optical Diagnostics for Studying Energetic Materials: A Review

Yiyang Zhang, Sen Chen, Yang Cai, Lei Lu, Duan Fan, Jinchun Shi, Junyu Huang, Sheng-Nian Luo

Journal Article

The research progress of laser combustion diagnostics techniques and applications

Hu Zhiyun,Liu Jingru,Zhang Zhenrong,Ye Jingfeng,Guan Xiaowei,Zhang Lirong,Wang Sheng,Huang Meisheng,Zhao Xinyan,Ye Xisheng

Journal Article